The Pack went on a 12-4 run at the end of the first half to lead for the first time but they couldn’t keep it going in the second half.
Clemson scored the first seven points of the second half and never looked back.
The Tigers worked the lead up to 14 before State, pressing full court, went on a 7-0 of its own to cut it to 56-49.
But midway through the half, the Wolfpack went cold and failed to score for seven minutes and it was never close down the stretch.
T.J. Warren led the Pack with 20 points and five rebounds, but he also committed six turnovers.
The Wolfpack falls to 16-10 overall and 6-7 in the ACC.